Trimethylsilyl iodide → HCID 54197837, compound

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Reaction Steps

tert-Butyl (4R)-3-2-aminoacetyl)-2-[(2RS)-5-norbornen-2-yl]-4-thiazolidinecarboxylate (mixture of isomers C and D) may be prepared in a manner similar to that described in Example 1B, but starting with 1.0 g of tert-butyl (4R)-3-(2-tert-butoxycarbonylaminoacetyl)-2-[(2RS)-5-norbornen-2-yl]-4-thiazolidinecarboxylate (mixture of isomers C and D) and 0.36 cm3 of iodotrimethylsilane. 0.77 g of tert-butyl (4R)-3-(2-aminoacetyl)-2-[(2RS)-5-norbornen-2-yl]-4-thiazolidinecarboxylate (mixture of isomers C and D) is thereby obtained in the form of a yellow oil, which is used in the subsequent syntheses without further treatment.

Provenance & Evidence