Ammonium formate → HCID 22872994, compound

Participants

Reaction Steps

The procedure is as in Example 1, but starting with 0.2 g of benzyl (4R)-3-[3-{2-[4-tert-butoxycarbonyl-2-[(2RS)-5-norbornen-2-yl]-3-thiazolidinyl]-2-oxoethyl}ureido]phenylacetate (mixture of isomers C and D), 0.13 g of Ammonium formate and 0.2 g of palladium on charcoal (10% Pd). 0.07 g of (4R)-3-[3-{2-[4-tert-butoxycarbonyl-2- ((2RS) -2-norbornyl)-3-thiazolidinyl]-2-oxoethyl}ureido]phenylacetic acid (mixture of isomers C and D) is thereby obtained in the form of a white product, melting point 115° C.

Provenance & Evidence