Ammonium formate → HCID 53961903, compound

Participants

Reaction Steps

The procedure is similar to that described in Example 1, but starting with 1.18 g of benzyl (4R)-3-{3-[2-(4-tert-butoxycarbonyl-2-butyl-3-thiazolidinyl)-2-oxoethyl]ureido}benzoate (isomer A), 0.8 g of ammonium formate and 1.2 g of palladium on charcoal (10% Pd). 0.25 g of (4R) -3-{3- [2- (4-tert-butoxycarbonyl-2-butyl-3-thiazolidinyl)-2-oxoethyl]ureido}benzoic acid (isomer A) is thereby obtained in the form of an amorphous products [α]D25 =-35.4°±1.0° (C %=0.52; DMF).

Provenance & Evidence