HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-(2,2-diethoxyethyl)-2,3-dihydrobenzo[b]furan-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Reactant | 2,3-Dihydro-1-benzofuran-4-amine | HCID 11701043 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2,2-diethoxyethyl)-2,3-dihydrobenzo[b]furan-4-amine | HCID 19046252 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2,3-dihydro-benzofuran-4-ylamine (preparation. J. Hetereocyclic Chem., 18, 1333 (1980)) (4.34 g), potassium carbonate (8.87 g) and bromo acetaldehyde diethyl acetal (9.7 ml) in dry DMF (60 ml) was heated to 100° C. for 2 days under. The mixture was cooled and was partitioned between water and ethyl acetate. The dried extracts were evaporated and the residue chromatographed on silica gel (250 g). Elution with ethyl acetate:cyclohexane 1:4 gave the title compound as a pale yellow oil (4.95 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05633276 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-83e005a4175642fe9afc52764d88855b |
| Source note | uspto-grants-1997_05 |