Hydrochloric Acid → HCID 19045345, compound

Participants

Reaction Steps

A solution of 0.216 g (0.75 mmol) 1'-acetyl-1,3-dihydro-1-oxo-6-nitrospiro[2H-indene-2,4'-piperidine] and 2 ml (6 mmol) 3N hydrochloric acid in 6 ml ethanol was heated at reflux for 18 hours. Another 0.2 ml (0.6 mmol) 3N hydrochloric acid was added and the solution was heated at reflux for 4 hours, then cooled to room temperature to give a white precipitate. The precipitate was filtered off, washed with ethanol, and dried to give 0.158 g (74%) product; 1H NMR (DMSO-d6): δ1.60 (d, 2H), 1.96 (m, 2H), 3.06 (m, 2H), 3.3 (m, 4H), 7.88 (d, 1H), 8.35 (d, 1H), 8.55 (d of d, 1H), 8.9 (broad s, 2H).

Provenance & Evidence