2H-Pyran-2-one → HCID 19045574, compound

HRID 1781429Notes

Reaction equation

HRID 1781429 reaction equation
[NH2:1][C:2]1[C:25]([N+:26]([O-])=O)=[CH:24][C:5]2[C:6](=[O:23])[CH2:7][C:8]3([O:22][C:4]=2[CH:3]=1)[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:10][CH2:9]3.O1C=CC=CC1=O>>[NH2:26][C:25]1[C:2]([NH2:1])=[CH:3][C:4]2[O:22][C:8]3([CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH2:10][CH2:9]3)[CH2:7][C:6](=[O:23])[C:5]=2[CH:24]=1

Participants

3

Reactant 2

HCID 681542H-Pyran-2-oneHCID 19045341HCID 19045341, compound

Product 1

HCID 19045574HCID 19045574, compound

Procedure

In the manner of Example 462, 7-amino-3,4-dihydro-6-nitro-1'-(2-phenylethyl)-spiro[(2H)-1-benzopyran-2,4'-piperidine]-4-one (1.22 g, 3.2 mmol) was reduced to give, after chromatography, the pyranone as a yellow foam (790 mg, 70%).

Workup

  1. customto give

Sources & evidence

ORD record
ord-01704057fb1b46e68a95066687aba699
Source dataset
uspto-grants-1997_05
Patent number
US05633247

Reaction notes

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