HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroanisole → 1-(3-Fluoro-4-methoxyphenyl)-2-[4-(methylthio)phenyl]-ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroanisole | HCID 67576 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 4-(Methylthio)phenylacetyl chloride | HCID 15020187 | — |
| Product | 1-(3-Fluoro-4-methoxyphenyl)-2-[4-(methylthio)phenyl]-ethan-1-one | HCID 21265703 | — |
Reaction Steps
1-(3-Fluoro-4-methoxyphenyl)-2-[4-(methylthio)phenyl]-ethan-1-one was prepared by Friedel Crafts acylation of 2-fluoroanisole with 4-(methylthio)phenylacetyl chloride in the presence of aluminum chloride: 1H NMR (CDCl3 /300 MHz) δ 7.80-7.70 (m, 2H), 7.24-7.15 (m, 4H), 6.98 (t, J=8.26 Hz), 4.17 (s, 2H), 3.95 (s, 3H), 2.46 (s, 3H). 19F NMR (CDCl3 /282.2 MHz): -134.804 (m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05633272 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-68b1442a02a241839e065e5997471261 |
| Source note | uspto-grants-1997_05 |