HCID 10279786, compound → HCID 10110008, compound

HRID 1781458Notes

Reaction equation

HRID 1781458 reaction equation
CC([C:4]1[CH:9]=[C:8](C(C)C)[CH:7]=[C:6](C(C)C)[C:5]=1[CH2:16][C:17]([C:19]1[C:20]([CH:33]([CH3:35])[CH3:34])=[C:21]([O:28][S:29](=[O:32])(=[O:31])[NH2:30])[C:22]([CH:25]([CH3:27])[CH3:26])=[CH:23][CH:24]=1)=[O:18])C.C(C1C=C(C(C)C)C=C(C(C)C)C=1C[Mg]Br)(C)C.C([Mg]Cl)C1C=CC=CC=1>>[C:5]1([CH2:16][C:17]([C:19]2[C:20]([CH:33]([CH3:35])[CH3:34])=[C:21]([O:28][S:29](=[O:31])(=[O:32])[NH2:30])[C:22]([CH:25]([CH3:27])[CH3:26])=[CH:23][CH:24]=2)=[O:18])[CH:6]=[CH:7][CH:8]=[CH:9][CH:4]=1

Participants

4

Reactant 3

HCID 10279786HCID 10279786, compoundHCID 178418336HCID 178418336, compoundHCID 178439061HCID 178439061, compound

Product 1

HCID 10110008HCID 10110008, compound

Procedure

This compound was prepared in the same manner as the title compound of Example 5, except that 2,4,6-triisopropylbenzyl magnesium bromide was replaced with benzylmagnesium chloride (commercially available), mp 150°-152° C.

Sources & evidence

ORD record
ord-82d527b28f674730844aadda2b4b4560
Source dataset
uspto-grants-1997_05
Patent number
US05633287

Reaction notes

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