trans-2-Phenylcyclopropanecarboxylic acid → Sulfamic acid trans-[(2-phenylcyclopropyl)carbonyl]-2,6-bis(1-methylethyl)phenyl ester

HRID 1781465Notes

Reaction equation

HRID 1781465 reaction equation
CC([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10](C)[CH3:11])[C:5]=1[CH2:13][C:14]([C:16]1[C:17]([CH:30]([CH3:32])[CH3:31])=[C:18]([O:25][S:26](=[O:29])(=[O:28])[NH2:27])[C:19]([CH:22]([CH3:24])[CH3:23])=[CH:20][CH:21]=1)=[O:15])C.C(C1C=CC=C(C(C)C)C=1CC(O)=O)(C)C.C1([C@@H]2C[C@H]2C(O)=O)C=CC=CC=1>>[C:6]1([C@@H:5]2[CH2:4][C@H:13]2[C:14]([C:16]2[C:17]([CH:30]([CH3:32])[CH3:31])=[C:18]([O:25][S:26](=[O:29])(=[O:28])[NH2:27])[C:19]([CH:22]([CH3:23])[CH3:24])=[CH:20][CH:21]=2)=[O:15])[CH:7]=[CH:8][CH:9]=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 237413trans-2-Phenylcyclopropanecarboxylic acidHCID 10226443Sulfamic acid[[2,6-bis(1-methylethyl)phenyl]-acetyl]-2,6-bis(1-methylethyl)phenyl esterHCID 152779902-(2,6-Diisopropylphenyl)acetic acid

Product 1

HCID 10222693Sulfamic acid trans-[(2-phenylcyclopropyl)carbonyl]-2,6-bis(1-methylethyl)phenyl ester

Procedure

This compound was prepared in the same manner as for the title compound of Example 1, except that 2,6-diisopropylphenylacetic acid was replaced with trans-2-phenylcyclopropylcarboxylic acid, mp 166°-168° C.

Sources & evidence

ORD record
ord-b1a0f5d6526b462fa06c1340d84034a8
Source dataset
uspto-grants-1997_05
Patent number
US05633287

Reaction notes

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