Sodium Hydroxide → HCID 19046533, compound

Participants

Reaction Steps

3-[2,4,6-Tris(1-methylethyl)phenyl]propionic acid, methyl ester (2.12 g, 7.3 mmol) was dissolved in 100 mL methanol and 10 mL water. Sodium hydroxide (0.32 g, 8.0 mmol) was added and the resulting solution was stirred at room temperature for 4 hours. Concentrated in vacuo and partitioned the residue between water and diethyl ether. The aqueous layer was acidified with concentrated HC1 and extracted with dichloromethane. The organic extract was dried over MgSO4, filtered, and concentrated to give 1.87 g of 3-[2,4,6-tris(1-methyl-ethyl)phenyl]propionic acid as a white solid, mp 194°-196° C.

Provenance & Evidence