反应详情

To a mixture of mandelonitrile (5 g) and chlorobenzene (15.7 g) was added sulfuric acid (9.8 ml) dropwise while the temperature of the mixture was maintained at 5°-10° C. After completion of dropwise addition, the mixture was stirred for another 1.5 hours. This reaction mixture was poured in ice-water and the syrup that had separated out was extracted into ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous sodium sulfate, and concentrated to dryness. The group was purified by silica gel column chromatography to provide the title compound (3.6 g) as pale yellow syrup.

1. temperaturewas maintained at 5°-10° C
2. additionAfter completion of dropwise addition
3. customthe syrup that had separated out
4. extractionwas extracted into ethyl acetate
5. washThe extract was washed with saturated aqueous sodium hydrogen carbonate solution
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated to dryness
8. customThe group was purified by silica gel column chromatography