Methanol → HCID 19045804, compound

Participants

Reaction Steps

In 20 ml of methanol was dissolved 0.80 g of 3,4-dihydrospiro[naphthalene-2(1H),2'-piperidin]-one and following addition of 0.15 g of sodium borohydride in small portions, the mixture was stirred for 30 minutes. The reaction mixture was then diluted with water and extracted with methylene chloride. The methylene chloride layer was dried over anhydrous sodium sulfate and filtered and the solvent was distilled off. The solid group was recrystallized from methylene chloride-ether to provide 0.25 g of white crystals.

Provenance & Evidence