Hydrochloric Acid → HCID 19029016, compound

Participants

Reaction Steps

In 30 ml of trifluoroacetic acid was dissolved 6.57 g of 3,4-dihydro-6-methoxyspiro[naphthalene-2(1H),2'-piperidin]-1-one followed by addition of 8.5 ml of triethylsilane and the mixture was stirred for 1 hour. This reaction mixture was poured portionwise in water. To this was added 1N-hydrochloric acid and the mixture was washed with hexane. The aqueous layer was made basic to 1N-aqueous sodium hydroxide and extracted with methylene chloride. The methylene chloride layer was dried over anhydrous sodium sulfate and filtered and the solvent was distilled off. The group was treated with 7.0 ml of 4N-methanolic hydrochloric acid to give a solid. This solid was recrystallized from methanol-ether to provide 5.09 g of white crystals.

Provenance & Evidence