Sodium Hydroxide → HCID 19045621, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (114 mg, 3 mmol) and aluminum chloride (400 mg, 3 mmol) in ether (4 ml) was added the suspension of 3,4-dihydro-6,7-dimethoxy-4'-methylspiro[naphthalene-2(1H),2'-piperazine]-3',6'-dione (50 mg, 0.16 mmol) in ether (2 ml). The reaction mixture was stirred at ambient temperature for 45 min and treated with 1N sodium hydroxide. The precipitate was filtered and washed with 1N sodium hydroxide and chloroform. The filtrate was washed with sat. sodium chloride, dried, and concentrated to give the titled compound (42 mg, 86%). A portion was dissolved in ethyl acetate and treated with 4N hydrochloric acid in ethyl acetate. Concentration under reduced pressure followed by addition of isopropylether gave a powder.

Provenance & Evidence