Hydrochloric Acid → HCID 22858936, compound

Participants

Reaction Steps

To methyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2,4-dimethyl-4-hexenoate (0.85 g) in methanol (10 ml) was added a solution of lithium hydroxide (0.4 g) in water (5 ml). After 4 hours at room temperature, the solution was poured into ice water, acidified with 10% aqueous hydrochloric acid, and extracted with ethyl acetate. The extract was dried and evaporated to give (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2,4-dimethyl -4-hexenoic acid, mp 120°-3° C. (tert-butylmethyl ether/hexane).

Provenance & Evidence