HRID1781529

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C=O)=P(c1ccccc1)(c1ccccc1)c1ccccc1

HCID4280987

2-(Triphenylphosphoranylidene)propionaldehyde

C21H19OP

结构：COCCOCOc1c(CC=O)c(OC)c(C)c2c1C(=O)OC2

HCID11120885

未命名化合物

PRODUCTS

生成物

$结构：COCCOCOc1c(C/C=C(\C)C=O)c(OC)c(C)c2c1C(=O)OC2$

HCID88264149

(E)-4-(1,3-dihydro-6-methoxy-4-methoxyethoxymethoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2-methylbut-2-enaldehyde

C19H24O7

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 2-(1,3-dihydro-6-methoxy-4-methoxyethoxymethoxy -7-methyl-3-oxoisobenzofuran-5-yl)acetaldehyde (10.3 g) and 2-(triphenyl-phosphoranylidene)-propionaldehyde (11.6 g) in toluene (250 ml) was refluxed for 7 hours. The solvent was removed under vacuum and the residue was chromatographed on silica gel, eluting with 9:1 hexane:ethyl acetate, to afford (E)-4-(1,3-dihydro-6-methoxy-4-methoxyethoxymethoxy-7-methyl -3-oxoisobenzofuran-5-yl)-2-methylbut-2-enaldehyde, mp 67°-68° C., (methylene chloride/hexane).

WORKUP

后处理

customThe solvent was removed under vacuum
customthe residue was chromatographed on silica gel
washeluting with 9:1 hexane