HCID 86750885, compound → HCID 70303102, compound

HRID 1781531Notes

Reaction equation

HRID 1781531 reaction equation
[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13](\[CH3:24])/[CH:14]([OH:23])[C:15]([CH3:22])([CH3:21])[C:16]([O:18]CC)=[O:17])=[C:9]([O:25][CH3:26])[C:8]([CH3:27])=[C:7]2[C:3]=1[C:4](=[O:28])[O:5][CH2:6]2>CCOCC.C(OCC)(=O)C>[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13](\[CH3:24])/[CH:14]([OH:23])[C:15]([CH3:21])([CH3:22])[C:16]([OH:18])=[O:17])=[C:9]([O:25][CH3:26])[C:8]([CH3:27])=[C:7]2[C:3]=1[C:4](=[O:28])[O:5][CH2:6]2

Participants

3

Reactant 1

HCID 86750885HCID 86750885, compound

Product 1

HCID 70303102HCID 70303102, compound

Reagents, catalysts & solvents 1

HCID 21584169Diethylether ethylacetateSolvent

Procedure

By following the procedure of Example ZA-6A and substituting methyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl) 2,4-dimethyl-4-hexenoate with ethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2,2,4-trimethyl-3-hydroxy-4-hexenoate and the corresponding compounds of Formula I-ZA-M1 prepared as described in Part A above, there are obtained (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy -7-methyl-3-oxoisobenzofuran-5-yl)-2,2,4-trimethyl-3-hydroxy-4-hexenoic acid, m.p. 180°-181° C. (ether/ethyl acetate) and the corresponding compounds of Formula I-ZA-M2 (where Z2 is OH) as identified in the following table.

Workup

  1. customthe corresponding compounds of Formula I-ZA-M1 prepared

Sources & evidence

ORD record
ord-c8fe2bc179014416806c17e5f7ee215d
Source dataset
uspto-grants-1997_05
Patent number
US05633279

Reaction notes

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