1-Phenethylamine → HCID 86750893, compound

Participants

Reaction Steps

A solution of the 85:13 acid mixture(E) 6-(1,3-dihydro-4-hydroxy -6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2,4-dimethyl-4-hexenoic acid (810 g, 2.4 mol,) was dissolved in acetone (16L) at 40° C. and (+)-α-methylbenzylamine (800 g, 6.6 mol) was added. Upon cooling, the salt crystallized and was collected by filtration. Recrystallization from acetone (8L) containing (+)-α-methylbenzylamine (202 g) afforded (E) 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl) -2,4-dimethyl-4-hexenoic acid (+)α-Methylbenzylamine salt after drying as off-white needles, m.p. 147°-9° C.

Provenance & Evidence