HCID 86750895, compound → HCID 15296124, compound

HRID 1781561Notes

Reaction equation

HRID 1781561 reaction equation
[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13]2/[CH2:14][CH:15]([C:18]([O:20]CC)=[O:19])[CH2:16][CH2:17]/2)=[C:9]([O:23][CH3:24])[C:8]([CH3:25])=[C:7]2[C:3]=1[C:4](=[O:26])[O:5][CH2:6]2>CCCCCC.ClCCl>[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13]2/[CH2:14][CH:15]([C:18]([OH:20])=[O:19])[CH2:16][CH2:17]/2)=[C:9]([O:23][CH3:24])[C:8]([CH3:25])=[C:7]2[C:3]=1[C:4](=[O:26])[O:5][CH2:6]2

Participants

3

Reactant 1

HCID 86750895HCID 86750895, compound

Product 1

HCID 15296124HCID 15296124, compound

Reagents, catalysts & solvents 1

HCID 21226440Methylenechloride HexaneSolvent

Procedure

By following the procedure of Example ZA-6A and substituting methyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2,4-dimethyl-4-hexenoate with ethyl (E)-3-[2-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)ethylidene]cyclopentane -1-carboxylate (prepared e.g, as described with reference to Reaction Scheme ZD-A, Steps 1 through 4) there is obtained (E)-3-[2-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)ethylidene]cyclopentane -1-carboxylic acid, m.p. 128°-130° C. (hexane-dichloromethane).

Sources & evidence

ORD record
ord-07739d7edf5d440498c0eb8a27b6ce82
Source dataset
uspto-grants-1997_05
Patent number
US05633279

Reaction notes

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