HCID 86749280, compound → HCID 22855617, compound

HRID 1781568Notes

Reaction equation

HRID 1781568 reaction equation
[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13](/[CH:15]2[CH2:19][CH2:18][CH2:17][CH:16]2[C:20]([O:22]CC)=[O:21])\[CH3:14])=[C:9]([O:25][CH3:26])[C:8]([CH3:27])=[C:7]2[C:3]=1[C:4](=[O:28])[O:5][CH2:6]2>CCCCCC.C(OCC)(=O)C>[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13](/[CH:15]2[CH2:19][CH2:18][CH2:17][CH:16]2[C:20]([OH:22])=[O:21])\[CH3:14])=[C:9]([O:25][CH3:26])[C:8]([CH3:27])=[C:7]2[C:3]=1[C:4](=[O:28])[O:5][CH2:6]2

Participants

3

Reactant 1

HCID 86749280HCID 86749280, compound

Product 1

HCID 22855617HCID 22855617, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By following the procedure of Example ZA-6A and substituting methyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran -5-yl)-2,4-dimethyl-4-hexenoate with ethyl (E)-2-[-3-(4-hydroxy-1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-1-methylpropenyl ]-cyclopentane-carboxylate and compounds of Formula I-ZH-A1, prepared e.g, as described in Example ZH-6B, there are obtained (E)-2-[-3-(1,3-dihydro-4-hydroxy -6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-1-methylpropenyl]-cyclopentane-carboxylic acid, mp 157°-158° C. (hexane/ethyl acetate) and the corresponding compounds of Formula I-ZH-A2 as identified in the following table.

Workup

  1. customprepared e.g

Sources & evidence

ORD record
ord-8a7d68a9fc10428b81c893f585c53f4a
Source dataset
uspto-grants-1997_05
Patent number
US05633279

Reaction notes

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