Pyrimidin-5-amine → HCID 178512303, compound

Participants

Reaction Steps

A stirred mixture of diphenyl cyanocarbonimidate (1.05 g, 0.00442 mol), 5-amino-pyrimidine (0.42 g, 0.00442 mol) and Et2O (15 mL) was kept at ambient temperature for 4 days and at reflux for one day. There was little reaction. The solvent was evaporated and the residue was mixed with DME and warmed at 50°-55° for 2 days. The mixture was cooled, diluted with Et2O and filtered; the solid was washed with Et2O and dried to give 0.57 g of N'-Cyano-N-(5-pyrimidyl)-O-phenylisourea product.

Provenance & Evidence