Methyl isothiocyanate → HCID 15171119, compound

Participants

Reaction Steps

A mixture of 4.07 g of 2-chloro-5-aminopyridine, 2.55 g of methyl isothiocyanate and 30 ml of acetonitrile was refluxed for 13.5 hours, to which 0.70 g of additional methyl isothiocyanate was added and the mixture was refluxed for 3.5 hours. The reaction mixture was concentrated, and the residue was purified by a column chromatography [developing solvent: dichloromethaneethyl acetate (1:1)] to afford 4.51 g of 1-(6-chloro-3-pyridyl)-3-methylthiourea.

Provenance & Evidence