Acetic Anhydride → HCID 136058307, compound

HRID 1781587Notes

Reaction equation

HRID 1781587 reaction equation
[CH3:1][S:2][C:3](=[NH:8])[NH:4][N+:5]([O-:7])=[O:6].[C:9](OC(=O)C)(=[O:11])[CH3:10]>N1C=CC=CC=1>[C:9]([NH:8][C:3](=[N:4][N+:5]([O-:7])=[O:6])[S:2][CH3:1])(=[O:11])[CH3:10]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 136058307HCID 136058307, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a mixture of 5.0 g of S-methyl-N-nitroisothiourea and 25 ml of pyridine was dropwise added 11.3 g of acetic anhydride at room temperature, taking for 10 minutes, followed by stirring for 5 hours at the same temperature. The reaction mixture was concentrated, and the residue was poured into 50 ml of 2N-hydrochloric acid. The resulting solid was collected by filtration and dried to obtain 5.1 g of N-acetyl-S-methyl-N'-nitroisothiourea. mp. 109°-110° C.

Workup

  1. customat room temperature
  2. concentrationThe reaction mixture was concentrated
  3. additionthe residue was poured into 50 ml of 2N-hydrochloric acid
  4. filtrationThe resulting solid was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-202a43352c1f4b68988506e8d117a5f3
Source dataset
uspto-grants-1997_05
Patent number
US05633375

Reaction notes

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