HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Aminomethyl)-2-chloropyridine → 1-(6-Chloro-3-pyridylmethyl)-3-methyl2-nitroguanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Aminomethyl)-2-chloropyridine | HCID 7020927 | — |
| Reactant | 1,2-Dimethyl-3-nitroisothiourea | HCID 136227017 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(6-Chloro-3-pyridylmethyl)-3-methyl2-nitroguanidine | HCID 136218196 | 34% |
Reaction Steps
A mixture of 0.45 g of 1,2-dimethyl-3-nitroisothiourea, 0.43 g of 5-(aminomethyl)-2-chloropyridine and 25 ml of ethanol was refluxed for 6 hours and concentrated. The residue was purified by a column chromatography [developing solvent: chloroform-ethanol (5:1)] to afford 0.25 g of 1-(6-chloro-3-pyridylmethyl)-3-methyl-2-nitroguanidine (Compound No. 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05633375 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-a0d445180fdc49e09290c6b0997b3fc5 |
| Source note | uspto-grants-1997_05 |