Cyanamide → HCID 178485034, compound

Participants

Reaction Steps

A mixture of 1.03 g of 1-(6-chloro-3-pyridyl)-3-methylthiourea, 0.32 g of cyanamide, 1.58 g of dicyclohexylcarbodiimide, 3 drops of ethyl diisopropylamine and 10 ml of acetonitrile was stirred for 34 hours at room temperature and filtered to collect an insoluble substance. The insoluble substance was recrystallized from a mixed solvent of acetonitrile and methanol, and then from acetonitrile to obtain 0.31 g of 1-(6-chloro-3-pyridyl)-2-cyano-3-methylguanidine (Compound No. 24).

Provenance & Evidence