2-Phenylimidazole → 2-Cyclohexyl-1H-imidazole

Participants

Reaction Steps

To a solution of 6.8 g of 2-phenylimidazole in 200 mL 3N hydrochloric acid was added 5% Rhodium on Carbon, Degussa type G10 NB/W. The mixture was hydrogenated at 100 psi for 24 hours then filtered through celite. The solution was neutralized with sodium hydroxide and extracted with 2×100 mL ethyl acemic. The combined extract was washed with 200 mL of brine and dried over anhydrous sodium sulfate. Evaporation of the solvent gave 2-cyclohexylimidazole as a fluffy, white solid which was used in the step without further purification or characterization.

Provenance & Evidence