Sodium Hydroxide → HCID 178518972, compound

HRID 1781617Notes

Reaction equation

HRID 1781617 reaction equation
[OH-:1].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[C:14](Cl)=[N:13][N:12]=[N:11]1>O>[CH:7]1[CH:6]=[C:5]([N:10]2[NH:11][N:12]=[N:13][C:14]2=[O:1])[C:4]([Cl:3])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 153465581-(2-Chloro-phenyl)-5-chlorotetrazole

Product 1

HCID 178518972HCID 178518972, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Conditions

Temperature
110 °C

Procedure

A solution of sodium hydroxide (13 g, about 45% by weight) in water, 1-(2-chloro-phenyl)-5-chlorotetrazole (12.9 g) in water (6.5 ml) were mixed and the mixture was heated to 110° C. The reaction was initiated and the temperature increased to 115° C. After 3 minutes from the initiation of the reaction, the temperature was lowered to room temperature and then water (20 ml) was added. The insoluble matter was extracted with toluene (10 ml) and the aqueous solution was adjusted to a pH of 1. The solid matter was collected by filtration followed by washing with water and drying to obtain a pale tan solid 1-(2-chlorophenyl)-5(4H)-tetrazolinone (11.3 g) (yield: 96%). melting point: 123°-125° C.

Workup

  1. temperaturethe temperature increased to 115° C
  2. customAfter 3 minutes from the initiation of the reaction
  3. customwas lowered to room temperature
  4. extractionThe insoluble matter was extracted with toluene (10 ml)
  5. filtrationThe solid matter was collected by filtration
  6. washby washing with water
  7. customdrying

Sources & evidence

ORD record
ord-a71703d6b6b4447d8aef3942b26b3745
Source dataset
uspto-grants-1997_05
Patent number
US05633387

Reaction notes

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