Hydrochloric Acid → HCID 54728090, compound

Participants

Reaction Steps

895 mg (2.73 mmol) of 7-chloro-4-hydroxy-3-(3-methoxycarbonylpropylthio)-2(1H)-quinolone are dissolved in 10 ml of 2N sodium hydroxide solution and the resulting solution is stirred for one hour at room temperature. The reaction mixture is adjusted to pH 2 with concentrated hydrochloric acid and the resulting white suspension is filtered and washed with water. The resulting colourless crystals are dried under a high vacuum at 70°, yielding 3-(3-carboxypropylthio)-7-chloro-4-hydroxy-2(1H)-quinolone in the form of colourless crystals having a melting point of 239°-241° (decomp.).

Provenance & Evidence