Dichloromethane → HCID 19046782, compound

Participants

Reaction Steps

14.2 g (82.3 mmol) of 3-chloro-5-nitro-aniline am dissolved under nitrogen at -65° in 235 ml of dichloromethane, and a solution of 9.8 ml (82.3 mmol) of tert-butyl hypochlorite in 30 ml of dichloromethane is added dropwise thereto. The mixture is then stirred for 10 minutes at -65° and then a solution of 10.6 ml (82.3 mmol) of methylthioacetic acid ethyl ester in 30 ml of dichloromethane is added dropwise thereto. The mixture is stirred for a further 1 hour at -65° and then a solution of 11.5 ml (82.3 mmol) of triethylamine is added dropwise thereto. The mixture is allowed to rise to room temperature, then washed with a small amount of water, dried over sodium sulfate, filtered and concentrated by evaporation. The evaporation residue is taken up in 250 ml of diethyl ether; 30 ml of 2N hydrochloric acid are added and the mixture is stirred at room temperature for 16 hours. The red precipitate is filtered off, washed with diethyl ether and dried. 8.48 g (40% of theon. 1) of 6-chloro-3-methylthio-4-nitro-quinolin-2-one having a melting point of 213° (decorap.) are obtained.

Provenance & Evidence