4-Toluenesulfonyl chloride → HCID 19046793, compound

Participants

Reaction Steps

9.87 g (51.7 mmol) of tosyl chloride in 50 ml of dichloromethane are added dropwise at room temperature to a solution of 6.5 g (47 mmol) of 3-(pyrimidin-5-yl)propanol and 9 ml (64.6 mmol) of triethylamine in 100 ml dichloromethane that is being stirred under nitrogen. The mixture is stirred for 16 hours at room temperature, then washed with water and saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated by evaporation under reduced pressure. 14.42 g of 3-(pyrimidin-5-yl)propyl tosylate are obtained, which can be processed further without further purification.

Provenance & Evidence