Water → HCID 178526185, compound

Participants

Reaction Steps

20 ml (40 mmol) of 2N sodium hydroxide solution are added dropwise to 7.8 g (32.5 mmol) of 3-(pyrimidin-5-yl)propylthioacetic acid ethyl ester in 20 ml of methanol. The mixture is then stirred for 16 hours at room temperature; a small amount of water is added and the mixture is extracted with dichloromethane, dried over sodium sulfate and filtered with suction and the filtrate is concentrated. 3.13 g (46% of theory) of 3-(pyrimidin-5-yl)propyl-thioacetic acid are obtained in the form of a brown oil.

Provenance & Evidence