Potassium Carbonate → HCID 67709740, compound

Participants

Reaction Conditions

Reaction Steps

3.5 g (15mmol) of 2-bromobenzenesulfonamide and 4.1 g K2CO3 are refluxed in dimethoxypropane for 1 hour. After that time 3 ml of n-propylisocyanate are added via a syringe. After additional 12 hours, the solution is cooled to 0° C., the pH is adjusted to 5-6 using 5% NaHSO4 and this mixture is extracted twice with ethyl acetate. The combined organic extracts are dried over MgSO4 and the solvent is removed. Cristallization from ethyl acetate furnishes the title compound. Rf =0.5 (E/H 2/1); MS (M+1)=321

Provenance & Evidence