Potassium Carbonate → 2-Iodobenzene n-propylsulfonylurea

Participants

Reaction Steps

To a stirred solution of 2-iodo benzene sulfonamide (4 g) in acetone (40 ml) solid K2CO3 (3.92 g) is added in one portion and the mixture is refluxed under N2 -atmosphere, n-propyl isocyanate is added dropwise to the heated mixture. After 2 hours reflux, the reaction is cooled to room temperature and concentrated to dryness. Water (200 ml) is added and the cooled mixture is acidified with 2N HCl to pH 4 and filtered. The precipitate obtained is recristallised with acetone/isopropyl ether mixture to give 4.1 g solid of the title compound. m.p.=211°-212° C.; IR (nujol): 3368, 1715, 1565, 1539 cm-1 ; MS (M+): 368

Provenance & Evidence