HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 5-(Imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(Imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide | HCID 21459143 | — |
Reaction Steps
A mixture of 2.78 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone, 1.01 g of 2-aminothiazole and 40 ml of ethanol is heated to boiling under reflux for 23 hours. The reaction mixture is then cooled to room temperature and the crystals are removed by filtration under suction. There is obtained 5-(imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide of m.p. 286°-288° (from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05633371 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-716cf179f82c4a828949e3494182d303 |
| Source note | uspto-grants-1997_05 |