2-Aminopyridine → 1,2-Benzenediol,5-imidazo[1,2-a]pyridin-3-yl-3-nitro-

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Reaction Steps

A mixture of 987.5 mg of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 1.01 g of 2-aminopyridine is melted at 110°. After 30 minutes the melt is treated with 15 ml of ethanol and heated to boiling under reflux for 3 hours. The reaction mixture is then cooled to room temperature and the crystals are removed by filtration under suction. There is obtained 5-(imidazo[1,2-a]pyridin-3-yl)-3-nitropyrocatechol of m.p. 250°-252° (from N,N-dimethylformamide/methanol).

Provenance & Evidence