HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridylthiourea → 3-Nitro-5-[2-(3-pyridylamino)-4-thiazolyl]pyrocatechol hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridylthiourea | HCID 2760515 | — |
| Reactant | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 3-Nitro-5-[2-(3-pyridylamino)-4-thiazolyl]pyrocatechol hydrobromide | HCID 21459051 | — |
Reaction Steps
A suspension of 7.32 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 4.06 g of 1-(3-pyridinyl)-2-thiourea in 100 ml of n-butanol and heated to boiling under reflux for 3 hours. After cooling to room temperature the crystals are filtered under suction and recrystallized from n-butanol. There is obtained 3-nitro-5-[2-(3-pyridylamino)-4-thiazolyl]pyrocatechol hydrobromide of m.p. >300°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05633371 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-ac0433796e55403c8260e8da36a03b90 |
| Source note | uspto-grants-1997_05 |