反应详情

5.4 g of 2-fluoro-3,4-dimethoxybenzyl acetate are heated to 80° for 1.5 hours together with 50 ml of methanol and 50 ml of 1N sodium hydroxide solution. After evaporation of the methanol the residue is extracted with methylene chloride. The combined extracts are washed with water, dried over sodium sulfate and evaporated. The residue is chromatographed on 80 g of silica gel with methylene chloride/methanol (95:5). 2-fluoro-3,4-dimethoxybenzyl alcohol is obtained as an oil.

1. customAfter evaporation of the methanol the residue
2. extractionis extracted with methylene chloride
3. washThe combined extracts are washed with water
4. dry with materialdried over sodium sulfate
5. customevaporated
6. customThe residue is chromatographed on 80 g of silica gel with methylene chloride/methanol (95:5)