HCID 21459115, compound → HCID 19000166, compound

HRID 1781903Notes

Reaction equation

HRID 1781903 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]([C:16]2[NH:17][C:18]3[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=3[N:20]=2)[OH:15])[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]=1[O:9][CH3:10]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:14]([C:16]2[NH:20][C:19]3[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=3[N:17]=2)=[O:15])[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 1

HCID 21459115HCID 21459115, compound

Product 1

HCID 19000166HCID 19000166, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

13.2 g of α-(3,4-dimethoxy-5-nitrophenyl)-2-benzimidazolemethanol are dissolved in 200 ml of methylene chloride and, after treatment with 130 g of manganese dioxide, the mixture is stirred at the reflux temperature for 2 hours. After filtration, the solvent is distilled. There is obtained 2-benzimidazolyl (3,4-dimethoxy-5-nitrophenyl) ketone in the form of yellowish crystals of m.p. 212°-213°.

Workup

  1. filtrationAfter filtration
  2. distillationthe solvent is distilled

Sources & evidence

ORD record
ord-b6049a0e1e50493580cda486cdbf10d0
Source dataset
uspto-grants-1997_05
Patent number
US05633371

Reaction notes

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