Potassium Carbonate → HCID 53782287, compound

Participants

Reaction Steps

To a solution of (S)-2-amino-1-((3,5-bis(trifluoromethyl) phenyl)methyloxy)-3,3-diphenylpropane (8.6 g, Example 1i) and anhydrous K2CO3 (13.0 g)in dimethylformamide (50 ml) was added methyl bromoacetate (4.5 ml). The reaction was stirred at room temperature for 0.75 h then diluted with ethyl acetate (200 ml) and washed with water (4×100 ml), brine (100 ml), dried over MgSO4 and evaporated to dryness. The residual oil was purified on silica gel eluting with petroleum ether-ethyl acetate mixtures to give (S)-N-(1-((3,5-bis(trifluoromethyl)phenyl) methyloxy)-3,3-diphenylprop-2-yl)glycine methyl ester as an oil (7.61 g) 1H NMR (360 MHz, CDCl3) δ7.77 (1H, s), 7.71 (2H, s), 7.42 (2H, d, J=7.4 Hz), 7.33-7.13 (8H, m), 4.44 (2H, s), 4.12 (1H, d, J=7.2 Hz), 3.73-3.69 (1H, m), 3.63 (3H, s), 3.57-3.52 (1H, m), 3.53 (2H, d, J=6.7 Hz) and 3.44-3.36 (1H, m).

Provenance & Evidence