HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1782008Generated: October 28, 2026
4-(N-Boc-amino)piperidine → {1-[2-(6-Cyano-quinolin-4-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/1782008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Reactant | 4-Vinyl-quinoline-6-carbonitrile | HCID 11492040 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | {1-[2-(6-Cyano-quinolin-4-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester | HCID 11574453 | 99.9% |
Reaction Steps
A mixture of (d) (150 mg, 0.8 mmol), piperidin-4-yl-carbamic acid tert-butyl ester (166 mg, 0.8 mmol) and chloroform (0.5 ml) were heated at 50° C. in a loosely capped vial for 6 hours. The product was purified by flash silica chromatography eluting with a 0-2% methanol in chloroform gradient affording the product as a foam (304 mg, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07498326B2 |
|---|
| Source dataset | uspto-grants-2009_03 |
|---|
| ORD ID | ord-281727cb74e9404f8ec80ef3f0e73d68 |
|---|
| Source note | uspto-grants-2009_03 |
|---|
