反应详情

温度

70 °C

The crude 2-chloro-8-benzyloxyquinoline from above was dissolved in toluene (10 mL) and added to a stirred 25 wt % solution of NaOMe in MeOH (50 mL). The reaction solution was heated with stirring overnight at 70° C. After cooling to room temperature, the reaction solution was poured onto ice and extracted with toluene. The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give a colorless oil (6.14 g, 92%). The product was used without further purification.

1. temperatureThe reaction solution was heated
2. temperatureAfter cooling to room temperature
3. additionthe reaction solution was poured onto ice
4. extractionextracted with toluene
5. dry with materialThe combined organic extracts were dried (MgSO4)
6. concentrationconcentrated in vacuo