HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guaiacol → HCID 86612851, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guaiacol | HCID 460 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86612851 | HCID 86612851 | 85.3% |
Reaction Steps
A mixture of (2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate (777 mg, 3.0 mmol), 2-methoxyphenol (372.5 mg, 3.0 mmol) and Cs2CO3 (1.3 g, 4.0 mmol) in DMF was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum spirit 40-60) to give subtitled compound (425 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07498338B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-68adbf71b21c4ac5a649a3d1da610519 |
| Source note | uspto-grants-2009_03 |