HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 86612854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| Reactant | N-[(2-Hydroxyphenyl)methyl]acetamide | HCID 12714526 | — |
| Product | HCID 86612854 | HCID 86612854 | 65.2% |
Reaction Steps
A mixture of N-(2-hydroxybenzyl)acetamide (382 mg, 2.31 mmol), (2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate (599 mg, 2.31 mmol) and Cs2CO3 (901 mg, 2.77 mmol) in DMP (5 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-80% ethyl acetate in petroleum spirit) to give the subtitled compound (333 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07498338B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-a891a99f7c7a4a67a6829b69796455f8 |
| Source note | uspto-grants-2009_03 |