1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichlorophenyl)-3-(6,7-dimethoxyquinazolin-4-yl)urea

HRID 1782068Notes

Reaction equation

HRID 1782068 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]=[O:11].[NH2:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1)=[O:11]

Participants

3

Reactant 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 130604516,7-Dimethoxyquinazolin-4-amine

Product 1

HCID 102718661-(2,6-Dichlorophenyl)-3-(6,7-dimethoxyquinazolin-4-yl)urea

Procedure

Using an analogous procedure to that described in Example 3, 2,6-dichlorophenyl isocyanate was reacted with 4-amino-6,7-dimethoxyquinazoline (European Patent Application No. 30156, Chemical Abstract volume 95, abstract 187290) to give the title compound; NMR Spectrum: (DMSOd6) 3.96 (s, 3H), 7.31 (m, 2H), 7.38 (t, 1H), 7.5 (d, 2H), 7.6 (d, 2H), 8.43 (s, 1H), 8.7 (s, 1H), 10.61 (s, 1H), 12.09 (s, 1H); Mass Spectrum M+H+ 393 & 395.

Sources & evidence

ORD record
ord-a352f3faeaec4e41acb986fc86af8a56
Source dataset
uspto-grants-2009_03
Patent number
US07498335B2

Reaction notes

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