Potassium Carbonate → HCID 10320864, compound

Participants

Reaction Conditions

Reaction Steps

The above sample of pyridine oxide was combined with (5R)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one (335 mg, 0.86 mMol, prepared as in Example 1), potassium carbonate (400 mg, 2.9 mMol), and tetrakis(triphenylphosphino)palladium(0) (80 mg, 0.07 mMol) and suspended in THF (10 ml) and water (1 ml). The mixture was heated at 75° C. for 2 hours, then diluted with water. The precipitated solids were collected on a filter, rinsed with water, ether and 1:1 methylene chloride:hexane and dried in vacuo to give the pure product as an off-white solid, 134 mg.

Provenance & Evidence