反应详情

温度

70 °C

(5R)-3-(3-Fluoro-4-iodophenyl)-5-[(4-hydroxymethyl-1H-1,2,3-triazol-1-yl)methyl]oxazolidin-2-one (5.7 g, 13.6 mmol) and manganese oxide (3.56 g, 40.9 mmol) were mixed and heated up to 100° C. in dry 1,4-dioxane for 48 hours, then the mixture was cooled down to 70° C. and filtered through celite. The filtrate was concentrated and dissolved in 5% methanol in dichloromethane, hexaneses was added and the formed precipitates were filtered and collected as the title compound (3.6 g).

1. filtrationfiltered through celite
2. concentrationThe filtrate was concentrated
3. dissolutiondissolved in 5% methanol in dichloromethane
4. additionhexaneses was added
5. customthe formed precipitates
6. filtrationwere filtered
7. customcollected as the title compound (3.6 g)