反应详情

A suspension of ethyl 2-azido-3-[3-(4-bromophenyl)-3H-imidazol-4-yl]acrylate (7) (240 mg) in p-xylene (10 mL) was heated at reflux under nitrogen for 30 min. The mixture was then cooled to rt, and the resulting white solid was collected by filtration, washed with hexane, and dried in air to yield ethyl 1-(4-bromophenyl)-1,4-dihydropyrrolo[2,3-d]imidazole-5-carboxylate EXAMPLE 1. LC-MS (ES+): m/z 334/336 (1/1) [MH+]. 1H NMR (CDCl3, 400 MHz): δ=1.40 (t, J=7.1 Hz, 3H), 4.38 (q, J=7.1 Hz, 2H), 6.94 (d, J=1.6 Hz, 1H), 7.43 (d, J=8.8 Hz, 2H), 7.65 (d, J=8.8 Hz, 2H), 7.93 (s, 1H), 8.99 (br s, 1H).

1. temperaturewas heated
2. temperatureat reflux under nitrogen for 30 min
3. filtrationthe resulting white solid was collected by filtration
4. washwashed with hexane
5. customdried in air