2',4'-Dihydroxyacetophenone → HCID 23110664, compound

Participants

Reaction Steps

2′,4′-Dihydroxyacetophenone (manufactured by Wako Pure Chemical Industries, Ltd.) was treated with 1-bromo-2-methyl-2-butene (manufactured by Aldrich) in 2 M KOH/methanol solution under ice-cooling, and thereafter the treated solution was hydrogenated in methanol, in the presence of palladium black (manufactured by Nakalai Tesque, Inc.), to give 2′,4′-dihydroxy-3′-(3-methylbutyl)acetophenone. Subsequently, 2′,4′-dihydroxy-3′-(3-methylbutyl)acetophenone and 4-hydroxybenzaldehyde (manufactured by Aldrich) were subjected to Claisen condensation, to give a yellow substance.

Provenance & Evidence