Trifluoroacetic acid → HCID 86608880, compound

Participants

Reaction Steps

tert-butyl 2-(2,2-dichloro-N-(3-(3-(2,6-dichlorophenyl)isoxazol-5-yl)phenyl)acetamido)ethylcarbamate (100 mg, 0.18 mmol) was dissolved in anhydrous dichloromethane (3 mL) and cooled in an ice-bath under nitrogen. Then trifluoroacetic acid (3 mL) was added. After 3 h at 4° C. the mixture was concentrated under reduced pressure. The residue was dissolved and concentrated under reduced pressure again to give N-(2-aminoethyl)-2,2-dichloro-N-(3-(3-(2,6-dichlorophenyl)isoxazol-5-yl)phenyl)acetamide trifluoroacetate salt as a white solid. 1H NMR (CDCl3): 8.04 (s, 1H), 7.65-7.62 (m, 2H), 7.43-7.30 (m, 4H), 6.73 (s, 1H), 5.95 (s, 1H), 4.21 (m, 2H), 3.35 ppm (m, 2H).

Provenance & Evidence