Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 1-[(1,2-Dimethyl-1H-imidazol-4-yl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 15-Crown-5 | HCID 36336 | — |
| 반응물 | 1,2-Dimethylimidazole-4-sulfonyl chloride | HCID 2736256 | — |
| 반응물 | 4-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 71362812 | — |
| 생성물 | 1-[(1,2-Dimethyl-1H-imidazol-4-yl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620765 | — |
반응 단계
By a reaction under similar conditions as in Reference Example 65 and using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 60 mg), 15-crown-5 (0.30 mL) and (1,2-dimethyl-1H-imidazol-4-yl)sulfonyl chloride (253 mg), the title compound was obtained as a colorless solid (yield 294 mg, 86%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07498337B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-06fbdbda795c41b9a710b107226f7644 |
| 출처 메모 | uspto-grants-2009_03 |